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KMID : 0374019820050010025
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Ewha Medical Journal
1982 Volume.5 No. 1 p.25 ~ p.32
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Experimental Model for Cerebral Infarction
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趙海龍/Cho, Hae Lyong
朴東彬/辛圭萬/Park, Dong Been/Shin, Kyu Man
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Abstract
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The purpose of this study is to report an experimental model for the cerebral infarction by occluding a segment of the middle cerebral artery with artificial emboli.
In each dog the right common carotid artery was exposed and the internal carotid artery vas catheterized selectively with a 16 gauge catheter of Intracath.
The prepared embolus, a gutter- Percha cylinder measuring 4 mm long by 1.5 mm in diameter was injected through the catheter of Intracath until backbleed. ing indicated the embolus had lodged intracranially, beyond the internal carotidmaxillary artery junction.
The optimal material for experimental emboli should be radiopaque and easily identified in pathological specimens, and should produce cerebral lesions which resemble spontaneously occuring clinical infarction in pathophysio logical mechanism.
Since the gutta percha cylinder is radiopaque and its position was able to be checked in simple skull films, it was considered to an optimal embolic material.
In the postoperative period the animals were extremely ill with. impaired consciousness, vomiting and contralateral hemiplegia.
Autopsy revealed massive hemorrhagic infarction of the ipsilateral cerebral hemisphere in each of the animals and the average volume of infarction was 1.93 cu cm and also it was observed that there was no endothelial damage of the middle cerebral artey, even when the embolus was left in situ for l0 days.
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